An Implantable Bio-Electro Scaffold for Brain Tissue Engineering

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Authors

  • Francisca Villanueva Flores National Autonomous University of Mexico
  • Andres Castro Lugo National Autonomous University of Mexico
  • Mathieu Hautefeuille National Autonomous University of Mexico
  • Laura A. Palomares National Autonomous University of Mexico

DOI:

https://doi.org/10.55549/ephels.64

Abstract

One of the main challenges for neural tissue engineering is to design scaffolds suitable for implantation that allow cell proliferation to provide an environment similar to the extracellular matrix. Here, films of poly(vinyl alcohol-co-vinyl) acetate (PAcVA) were printed with gold-functionalized nanotubes of rotavirus VP6 protein (nVP6Au) in ordered patterns in serie and in parallel to form the µChipVP6Au. The obtained bio-electrical material resulted in a biocompatible scaffold suitable for the culture of the embryonic mouse hypothalamus cell line mHypoE-N1. Then, the bio-electrical scaffold was implanted in the mice’s parietal cortex with no toxic effects observed. Our results showed that our bio-electrical implantable scaffold has tremendous potential as a platform for exogen cell implantation, a system for drug delivery, and an electrical scaffold for electrostimulation.

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Published

2023-09-01

How to Cite

Flores, F. V., Lugo, A. C., Hautefeuille, M., & Palomares, L. A. (2023). An Implantable Bio-Electro Scaffold for Brain Tissue Engineering. The Eurasia Proceedings of Health, Environment and Life Sciences, 10, 7–15. https://doi.org/10.55549/ephels.64

Issue

VOLUME 10 (2023)

Section

Articles

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Copyright (c) 2023 The Eurasia Proceedings of Health, Environment and Life Sciences

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